A global review of national guidelines of post‐exposure prophylaxis for the prevention of HIV

作者：Marcus Maisano, Daniel Tran, Virginia Macdonald, Rachel Baggaley, Nathan Ford, Cheryl Johnson, Ying Zhang, Jason J. Ong · 发表于：Journal of the International AIDS Society · 年份：2025 · DOI：10.1002/jia2.26333 · 被引用次数：11 · 研究领域：HIV/AIDS Research and Interventions、Infection Control in Healthcare、Safe Handling of Antineoplastic Drugs

INTRODUCTION: The World Health Organization (WHO) recommends the use of antiretroviral drugs as post-exposure prophylaxis (PEP) for preventing HIV acquisition for occupational and non-occupational exposures. To inform the development of global WHO recommendations on PEP, we reviewed national guidelines of PEP for their recommendations. METHODS: Policies addressing PEP from 38 WHO HIV priority countries were obtained by searching governmental and non-governmental websites and consulting country and regional experts; these countries were selected based on HIV burden, new HIV acquisitions and the number of HIV-associated deaths. We reviewed national guidelines to collate data on where PEP can be offered, who can prescribe PEP, PEP eligibility, recommended drug regime, linkage to other interventions, recommended investigations prescribed with PEP, HIV self-test recommendation related to PEP and stopping rules for PEP. RESULTS: In total, 46 guidelines from January 2010 to May 2023 across 36 countries were included, with 70% of documents published during or after 2020. There was significant variation across national guidelines regarding where PEP can be accessed and who can provide or prescribe PEP. Six countries (17%) described being able to access PEP from a primary care facility, four countries (11%) from hospitals and two (6%) from community-based services. Only three countries (8%) specifically considered dispensing PEP by professionals other than doctors (e.g. nurses). None m...