MRI detects tubulointerstitial changes in mouse models of radiation‐induced nephropathy

作者：Julia Stabinska, Joe Piccolo, Anupriya Chhabra, Ioanna Liatsou, Kathy Gabrielson, Zhi Li, Zinia Mohanta, Farzad Sedaghat, Robert F. Hobbs, George Sgouros, Michael T. McMahon · 发表于：Magnetic Resonance in Medicine · 年份：2025 · DOI：10.1002/mrm.30443 · 被引用次数：3 · 研究领域：MRI in cancer diagnosis、Advanced MRI Techniques and Applications、Lanthanide and Transition Metal Complexes

Abstract Purpose We hypothesized that radiation‐induced tubulointerstitial changes in the kidney can be assessed using MRI‐based T 2 relaxation time measurements. Methods We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an α‐particle‐emitting actinium‐225 radiolabeled antibody. We compared the mean T 2 values of different renal compartments between control and external beam radiotherapy or α‐particle‐emitting actinium‐225 radiolabeled antibody–treated groups and between the two radiation‐treated groups using a Wilcoxon rank‐sum test. Results Significantly higher T 2 values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group ( p < 0.05). In addition, these changes in T 2 were observed before any changes in serum parameters, animal body weight, and kidney volume occurred. Conclusion T 2 mapping is sensitive to radiation‐induced tubulointerstitial changes in the kidney.