Metrnl and Cardiomyopathies: From Molecular Mechanisms to Therapeutic Insights

作者：Miaomiao Xu, Xiaoguang Liu, Liming Lu, Zhaowei Li · 发表于：Journal of Cellular and Molecular Medicine · 年份：2025 · DOI：10.1111/jcmm.70371 · 被引用次数：6 · 研究领域：Cardiomyopathy and Myosin Studies、Viral Infections and Immunology Research、Cardiovascular Effects of Exercise

Cardiomyopathies, a diverse group of diseases affecting the heart muscle, continue to pose significant clinical challenges due to their complex aetiologies and limited treatment options targeting underlying genetic and molecular dysregulations. Emerging evidence indicates that Metrnl, a myokine, adipokine and cardiokine, plays a significant role in the pathogenesis of various cardiomyopathies. Therefore, the objective of this review is to examine the role and mechanism of Metrnl in various cardiomyopathies, with the expectation of providing new insights for the treatment of these diseases.