Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: a retrospective cohort study

作者：Shiqi Liu, Ziyang Wu, Gaoliang Yan, Yong Qiao, Yuhan Qin, Dong Wang, Chengchun Tang · 发表于：Diabetology & Metabolic Syndrome · 年份：2025 · DOI：10.1186/s13098-024-01575-7 · 被引用次数：6 · 研究领域：Hyperglycemia and glycemic control in critically ill and hospitalized patients、Cardiovascular Function and Risk Factors、Diabetes Management and Research

BACKGROUND: Stress hyperglycemia ratio is a novel indicator of acute coronary synthesis (ACS), which is closely related to the severity and complications of ACS and other cardiovascular diseases. However, its relationship with the progression of non target coronary lesions remains unclear. The purpose of this paper is to explore the relationship between stress hyperglycemia ratio and the progression of non target coronary lesions. METHODS: This study retrospectively enrolled patients diagnosed with acute coronary syndrome who underwent stent implantation and follow-up evaluations by coronary angiography at Zhongda Hospital between January 2019 and January 2024. Patients were classified into progression and non progression groups based on follow-up angiography findings. Logistic regression models, restricted cubic spline analysis, and machine learning algorithms (LightGBM, decision tree, and XGBoost) were utilized to analyse the relationship of stress hyperglycemia ratio and non target lesion progression. RESULTS: A total of 1,234 ACS patients were included; 29.1% experienced non target lesions progression. Logistic regression analysis showed that stress hyperglycemia ratio (SHR) was a risk factor for non target disease progression (P < 0.001), and after adjusting for other variables, SHR was still independently associated with non target disease progression (OR = 2.12, 95% CI: 1.30-3.44, p = 0.003). RCS analysis revealed a near-linear relationship between SHR and nontarget le...