Changes in infant respiratory pathogens pre-, during, and post-COVID-19 non-pharmacological interventions in Beijing

作者：Tongying Han, Yajuan Wang, Di Zhang, Ying Li, Zhang Li, Yan Jin, Chi Li, Shengnan Yang, Litao Guo, Huijuan Yan · 发表于：˜The œItalian Journal of Pediatrics/Italian journal of pediatrics · 年份：2025 · DOI：10.1186/s13052-025-01848-5 · 被引用次数：9 · 研究领域：Respiratory viral infections research、COVID-19 Impact on Reproduction、Pneumonia and Respiratory Infections

BACKGROUND: To explore the effect of non-pharmacological interventions (NPIs) on respiratory pathogen profiles among hospitalized infants aged 0-3 months in Beijing during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: Respiratory specimens were collected from 1,184 infants aged 0-3 months who were hospitalized for acute respiratory infection at the Children's Hospital affiliated with the Capital Institute of Pediatrics from January 2018 to December 2023. The data were divided into three groups-the pre-epidemic (January 2018 to December 2019), epidemic prevention and control (January 2020 to December 2022), and post-epidemic (January 2023 to December 2023) groups-based on the outbreak of COVID-19 and the implementation and termination of NPIs. The specimens were tested for 14 respiratory pathogens, including influenza virus A (Flu A), influenza virus B, respiratory syncytial virus, parainfluenza virus (PIV), adenovirus (ADV), human metapneumovirus (HMPV), human bocavirus, human rhinovirus (HRV), coronavirus, Chlamydia trachomatis, Chlamydia pneumoniae (C.pn), Mycoplasma pneumoniae, Bordetella pertussis, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RESULTS: A total of 1,184 infants, including 649 males and 535 females, with acute respiratory infections were admitted. The positive detection rate for respiratory pathogens was 51.77% (n = 613). In 2023, the proportion of infants with respiratory infections after the epidemic was 19.4% (319/1646), ...