Expert consensus on vitamin D in osteoporosis

作者：Lei Sha, Xiaoya Zhang, Lige Song, Jiang Wen, Zheng Zhang, Jianqing Tian, Rui Yang, Shuhang Xu, Shanhu Qiu, Richard J. MacIsaac, Jasna Aleksova, Fabrice Mac‐Way, Marie-Ève Dupuis, David Benaiges, Dı́dac Mauricio, Andrei P. Sommer, Joshua I. Barzilay, John C. Gallagher, Lingling Pan, Linlin Ji, Ping Fang, Ying Li, Qi Liu, Jiasheng Zhao, Ying Xue, Yuqin Shen, Lemin Wang, Junfeng Han, Guanghui Liu · 发表于：Annals of Joint · 年份：2025 · DOI：10.21037/aoj-24-48 · 被引用次数：13 · 研究领域：Vitamin D Research Studies、Bone health and osteoporosis research、HIV-related health complications and treatments

Background: Adequate vitamin D is essential for maintaining optimal bone health, preventing and treating of osteoporosis. However, in recent years, large clinical trials and meta-analyses on the efficacy of vitamin D supplementation to prevent fractures in populations at different risks have been equivocal. The optimal level of 25-hydroxyvitamin D (25[OH]D) remains controversial. Recommendations vary between societies. The lack of standardized assays also poses a challenge in interpreting available research data. Methods: We systematically searched for articles in MEDLINE database through PubMed, which included meta-analysis, systematic reviews of randomized controlled trials (RCTs) and observational studies that assessed measurement, diagnosis and treatment about vitamin D deficiency. The experts evaluated the available literature, graded references according to the type of study and described the strength recommendations. Results: This expert consensus is based on the review of relevant clinical evidence and provides nine key recommendations on vitamin D deficiency in populations at different risks, especially in patients with osteoporosis. Supporting information is provided in the subsequent appendix box. Conclusions: This expert consensus is a practical tool for endocrinologists, general physicians for the diagnosis, assessment, and treatment of populations at different risks of vitamin D deficiency, especially in patients with osteoporosis. Clinicians should be aware of ...