NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity

作者：Ruiyang Zi, Kaicheng Shen, Pengfei Zheng, Xingxing Su, Yishi Yang, Yanrong Chen, Haisu Dai, Chengyi Mao, Yongling Lu, Liting Wang, Hongbo Ma, Wei Wang, Qing Yun Li, Wei-Ting Lu, Chengtao Li, Shuangjia Zheng, Hui Shi, Xiaohong Liu, Zhiyu Chen, Houjie Liang, Juanjuan Ou · 发表于：The Innovation · 年份：2025 · DOI：10.1016/j.xinn.2024.100783 · 被引用次数：7 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer, Hypoxia, and Metabolism、Ferroptosis and cancer prognosis

T cells, and improved the anti-tumor immunity of PAAD to synergize with PD-1 blockade, suggesting NPC1L1 as a promising target to rescue the anti-tumor activity in PAAD.