Neurotransmitter-mediated artificial synapses based on organic electrochemical transistors for future biomimic and bioinspired neuromorphic systems

作者：Miao Cheng, Yifan Xie, Jinyao Wang, Qingqing Jin, Yue Tian, Changrui Liu, Jintao Chu, Mengmeng Li, Ling Li · 发表于：Journal of Semiconductors · 年份：2025 · DOI：10.1088/1674-4926/24090013 · 被引用次数：7 · 研究领域：Conducting polymers and applications、Advanced Memory and Neural Computing、Neuroscience and Neural Engineering

Abstract Organic electrochemical transistors have emerged as a solution for artificial synapses that mimic the neural functions of the brain structure, holding great potentials to break the bottleneck of von Neumann architectures. However, current artificial synapses rely primarily on electrical signals, and little attention has been paid to the vital role of neurotransmitter-mediated artificial synapses. Dopamine is a key neurotransmitter associated with emotion regulation and cognitive processes that needs to be monitored in real time to advance the development of disease diagnostics and neuroscience. To provide insights into the development of artificial synapses with neurotransmitter involvement, this review proposes three steps towards future biomimic and bioinspired neuromorphic systems. We first summarize OECT-based dopamine detection devices, and then review advances in neurotransmitter-mediated artificial synapses and resultant advanced neuromorphic systems. Finally, by exploring the challenges and opportunities related to such neuromorphic systems, we provide a perspective on the future development of biomimetic and bioinspired neuromorphic systems.