MgO@SiO 2 nanocapsules: a controlled magnesium ion release system for targeted inhibition of osteoarthritis progression

作者：Na Liu, Fangchao Jiang, Zhizi Feng, Sen Mei, Yingna Cui, Yu Zheng, Wei Yang, Benjie Wang, Weizhong Zhang, Jin Xie, Nan Zhang · 发表于：Nanoscale Advances · 年份：2025 · DOI：10.1039/d4na00900b · 被引用次数：12 · 研究领域：Bone Metabolism and Diseases、Orthopaedic implants and arthroplasty

nanocapsules alleviate the inflammatory response in OA cartilage by inhibiting the NF-κB/p65 signaling pathway. In summary, this study confirms the potential of intra-articular magnesium supplementation as a therapeutic option for OA and introduces a novel approach to enhance the delivery and efficacy of magnesium ions in OA treatment, addressing a relatively underexplored area in the field.