The role of phospholipid transfer protein in sepsis-associated acute kidney injury

作者：Wei Jiang, Song Lin, Weilei Gong, Xianghui Li, Keran Shi, Luanluan Li, Chuanqing Zhang, Jing Wang, Xiaolan Xu, Haixia Wang, Xiaoyan Wu, Jun Shao, Yang Yu, Jiangquan Yu, Ruiqiang Zheng · 发表于：Critical Care · 年份：2025 · DOI：10.1186/s13054-025-05253-6 · 被引用次数：4 · 研究领域：Acute Kidney Injury Research、Immune Response and Inflammation、Trauma, Hemostasis, Coagulopathy, Resuscitation

BACKGROUND: Phospholipid transfer protein (PLTP), a glycoprotein widely expressed in the body, is primarily involved in plasma lipoprotein metabolism. Previous research has demonstrated that PLTP can exert anti-inflammatory effects and improve individual survival in patients with sepsis and endotoxemia by neutralizing LPS and facilitating LPS clearance. However, the role of PLTP in sepsis-associated acute kidney injury (SA-AKI) and the specific mechanism of its protective effects are unclear. This study aimed to assess the potential role of PLTP in SA-AKI. METHODS: This is a population-based prospective observational study of patients with sepsis admitted to the intensive care unit. Blood samples were collected on days 1, 3, 5, and 7 after admission to the ICU. Plasma PLTP lipotransfer activity was measured to assess outcomes, including the incidence of SA-AKI and 30-day major adverse kidney events (MAKE 30). The correlation between PLTP lipotransfer activity and SA-AKI and MAKE 30 was evaluated through logistic regression modeling. Receiver operating characteristic curves were used to assess the diagnostic value of PLTP lipotransfer activity for SA-AKI and MAKE 30. The PLTP lipotransfer activity was categorized into high and low groups based on the optimal cut-off values. The differences between the high and low PLTP lipotransfer activity groups in terms of MAKE 30 were evaluated using Kaplan-Meier analysis. The SA-AKI mouse model was established via cecum ligation and punct...