RETRACTED: Astragalus polysaccharide reduces the severity of acute pancreatitis under a high-fat diet through enriching L. reuteri and propionate

作者：Qiang Wang, Xuxu Liu, Zhiwei Du, Yi Zheng, Ziang Meng, Zhenyi Lv, Liyi Wang, Dongbo Xue · 发表于：International Journal of Biological Macromolecules · 年份：2025 · DOI：10.1016/j.ijbiomac.2025.140021 · 被引用次数：5 · 研究领域：Liver Disease Diagnosis and Treatment、Pancreatitis Pathology and Treatment、Liver Diseases and Immunity

neutrophils and activation of the NF-κB/necroptosis pathway in HAP mice. Treatment with APS reduced neutrophil infiltration, downregulated NF-κB, and suppressed necroptosis. APS also restored gut microbiota balance, boosting Lactobacillus reuteri (L. reuteri) and propionate (PA) levels. Interventions with L. reuteri or PA reduced HAP severity, with combined treatment showing synergistic effects. These findings suggest that the protective effect of APS is mediated by microbiota-dependent mechanisms, highlighting the gut-pancreas axis as a potential therapeutic target for AP.