Evaluation of Real‐Time Cardiovascular Flow MRI Using Compressed Sensing in a Phantom and in Patients With Valvular Disease or Arrhythmia

作者：Tania Lala, Lea Christierson, Petter Frieberg, Daniel Giese, Peter Kellman, Nina Hakacova, Pia Sjöberg, Ellen Ostenfeld, Johannes Töger · 发表于：Journal of Magnetic Resonance Imaging · 年份：2025 · DOI：10.1002/jmri.29702 · 被引用次数：3 · 研究领域：Advanced MRI Techniques and Applications、Cardiac Imaging and Diagnostics、Lanthanide and Transition Metal Complexes

BACKGROUND: Real-time (RT) phase contrast (PC) flow MRI can potentially be used to measure blood flow in arrhythmic patients. Undersampled RT PC has been combined with online compressed sensing (CS) reconstruction (CS RT) enabling clinical use. However, CS RT flow has not been validated in a clinical setting. PURPOSE: Evaluate CS RT in phantom and patients. STUDY TYPE: Prospective. POPULATION: Flow phantom (60 cycles/min: N = 10, 120 cycles/min: N = 12), sinus rhythm patients, no regurgitation (N = 20) or suspected aortic regurgitation (N = 10), arrhythmia patients (N = 10). FIELD STRENGTH/SEQUENCE: 1.5 T, 2D gated PC, CS RT PC, RT cine with arrhythmia rejection. ASSESSMENT: Phantom experiments tested the accuracy of CS RT cardiac output and peak flow rate at 60 and 120 cycles/min against gated PC. For sinus rhythm patients, cardiac output, peak flow rate, and regurgitation fraction in the ascending aorta and/or pulmonary artery were evaluated against gated PC. Cardiac output in patients with arrythmia was evaluated against RT cine with arrhythmia rejection. STATISTICAL TESTS: Bland Altman, correlation, Mann-Whitney test, Wilcoxon signed-rank test. RESULTS: Cardiac output bias ± SD for CS RT in the phantom was -0.0 ± 0.2 L/min (0.5 ± 3%, P = 0.76) at 60 cycles/min and 0.2 ± 0.3 L/min (4 ± 4%, P = 0.0016) at 120 cycles/min. Correspondingly, peak flow rate bias was -23 ± 6 mL/s (-7 ± 2%, P < 0.0001) and -73 ± 25 mL/s (-23 ± 4%, P < 0.0001). In patients, regurgitant fraction was...