Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis

作者：Qiang Luo, Siyuan Chu, Yiqing Wu, Lingling Jin, Rui Liu, Yulin Xu, Yina Yu, Yawei Jin, Luckress Ornelle Edouarda Phyfamin Houndekon, Hua Hu, Yvchen Zou, Hao Huang, Haimin Chen · 发表于：BMC Oral Health · 年份：2025 · DOI：10.1186/s12903-025-05455-y · 被引用次数：5 · 研究领域：Oral microbiology and periodontitis research、Gut microbiota and health、Salivary Gland Disorders and Functions

BACKGROUND: Tongue-coating microbiota, especially known as the tongue microbiome, holds significant value as both a prospective clinical diagnostic biomarker and therapeutic target, which plays a crucial role in the oral microecological health. However, there is limited understanding of the composition and function of tongue coating microbiota in chronic kidney disease patients undergoing hemodialysis. METHODS: Thirty-one non-diabetic hemodialysis patients (nonDM_HD), 29 diabetic hemodialysis patients (DM_HD) and 33 healthy controls (HC) were enrolled. Swabs from tongue coating were collected. The 16S rDNA (V3-V4 region) was sequenced to scrutinize the tongue-coating bacterial microbiome difference. RESULTS: Both nonDM_HD and DM_HD showed distinct bacterial communities of oral microbiota compared to HC. The abundance of Streptococcus, Lactobacillus, Ruminococcaceae G1, Ligilactobacillus and Abiotrophia showed a significant increase (p < 0.05) in DM_HD and nonDM_HD compared to HC, while Haemophilus, Lachnoanaerobaculum, Peptostreptococcaceae G1, Peptostreptococcus showed a significant decrease (p < 0.05) respectively. Veillonella, Lactobacillus, Limosilactobacillus etc. may serve as potential biomarkers for DM_HD. While Streptococcus, Ruminococcaceae G1, Actinobacillus, Abiotrophia can be considered alternative biomarkers for nonDM_HD. Moreover, the enriched Haemophilus, Actinomyces, Lachnoanaerobaculum were prominent features of the tongue coating microbiota in HC, which coul...