Persistence of Retinal Fluid after Anti-VEGF Treatment for Neovascular Age-Related Macular Degeneration

作者：Dominic Wei Ting Yap, Benjamin Kye Jyn Tan, Kelvin Yi Chong Teo, Tien Yin Wong, Chui Ming Gemmy Cheung · 发表于：Ophthalmology Retina · 年份：2025 · DOI：10.1016/j.oret.2025.01.010 · 被引用次数：6 · 研究领域：Retinal Diseases and Treatments、Retinal Imaging and Analysis、Retinal and Macular Surgery

TOPIC: To evaluate the prognosis of retinal fluid resolution in neovascular age-related macular degeneration (nAMD) after initiating treatment in terms of the prevalence of eyes with retinal fluid, the proportion of eyes which never achieve a fluid-free retina throughout the course of treatment, and the relationship between retinal fluid and visual acuity outcome. CLINICAL RELEVANCE: Retinal fluid often persists or recurs after initiating treatment for nAMD. It is unclear what proportion never achieve fluid resolution throughout their treatment course. METHODS: MEDLINE, Embase, and Web of Science were searched till May 2024 for randomized control trials (including post hoc analyses) and prospective studies treating nAMD patients with intravitreal anti-VEGF injections (CRD42023437516). To investigate the prevalence of persistent fluid, a meta-analysis of proportions was conducted at key time points. To estimate the proportion of poor-responding patients, iterative algorithms were used to simulate individual patient data from time-to-fluid-resolution Kaplan-Meier curves. Cure fractions from Weibull nonmixture cure models were meta-analyzed. Finally, the weighted mean best-corrected visual acuity (BCVA) difference (WMD) between patients with and without any fluid, subretinal fluid (SRF), or intraretinal fluid (IRF) was calculated. RESULTS: Fifty articles were included across the meta-analyzed outcomes. The pooled prevalence of retinal fluid was 41.4% (95% confidence interval [CI...