Targeting farnesoid X receptor as aging intervention therapy

作者：Lijun Zhang, Jing Yu, Xiaoyan Gao, Yingxuan Yan, Xinyi Wang, Hang Shi, Minglv Fang, Ying Liu, Young‐Bum Kim, Huanhu Zhu, Xiaojun Wu, Cheng Huang, Shengjie Fan · 发表于：Acta Pharmaceutica Sinica B · 年份：2025 · DOI：10.1016/j.apsb.2025.01.006 · 被引用次数：8 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Circadian rhythm and melatonin、Stress Responses and Cortisol

. In addition, metabolome analysis revealed that OCA increased the endogenous agonist levels of the pregnane X receptor (PXR), a major nuclear receptor for detoxification regulation, in the liver of mice. Together, our findings suggest that OCA has the potential to lengthen lifespan and healthspan by activating nuclear receptor-mediated detoxification functions, thus, targeting FXR may offer to promote longevity.