Sleep Pattern, Lifestyle Pattern, and Risks of Overall and 20 Types of Cancers: Findings From the UK Biobank Cohort

作者：Yue Zhao, Wenli Zhang, Kaiwen Zhang, Yong‐Qiao He, Wen‐Qiong Xue, Dawei Yang, Hua Diao, Ruowen Xiao, Ying Liao, Qiao-Ling Wang, Wei‐Hua Jia, Tong‐Min Wang · 发表于：International Journal of Public Health · 年份：2025 · DOI：10.3389/ijph.2024.1607726 · 被引用次数：10 · 研究领域：Sleep and related disorders、Cancer survivorship and care、Nutritional Studies and Diet

Objectives: Sleep health and other lifestyle behaviours are gaining increasing attention in public health, particularly for cancer prevention, but a comprehensive assessment is lacking. Methods: The study included 380,042 UK Biobank participants. A healthy sleep score was constructed based on five sleep factors: chronotype, sleep duration, insomnia, snoring, and daytime dozing. A healthy lifestyle score was constructed based on four lifestyle factors: smoking, alcohol consumption, diet and physical activity. The effect of healthy sleep and lifestyle on cancer risk was examined by Cox proportional hazard models. Results: Both healthy sleep and lifestyle patterns were significantly associated with a reduced risk of overall cancer and specific cancer sites. Participants with healthy sleep and lifestyle patterns had a lower risk of overall cancer (HR = 0.72, 95% CI = 0.68-0.77), liver cancer (HR = 0.53, 95% CI = 0.31-0.90), bladder cancer (HR = 0.61, 95% CI = 0.47-0.79), lung cancer (HR = 0.22, 95% CI = 0.19-0.27), and colorectal cancer (HR = 0.80, 95% CI = 0.66-0.96) compared to those with unhealthy patterns. Conclusion: Our findings highlight the importance of public health education and interventions to improve sleep and other lifestyle behaviours for cancer prevention.