Vaccination against SARS-CoV-2 provides low-level cross-protection against common cold coronaviruses in mouse and non-human primate animal models

作者：Maedeh Naghibosadat, George Babuadze, Yanlong Pei, Jacklyn R. Hurst, Elsa Salvant, Kayla Gaete, Mia J. Biondi, Badru Moloo, Alyssa Goldstein, Stacey Avery, Ke Ma, Anna Pietraszek, Sarah K. Wootton, Assad Alhaboub, Benjamin Martin, Samira Mubareka, Juan Carlos Corredor, Azmiri Sultana, Adebayo Adeekoa, Patrick Budylowski, Mario Ostrowski, Jesse T. Chao, Éva Nagy, Robert Kozak · 发表于：Journal of Virology · 年份：2025 · DOI：10.1128/jvi.01390-24 · 被引用次数：4 · 研究领域：SARS-CoV-2 and COVID-19 Research、Animal Virus Infections Studies、Viral gastroenteritis research and epidemiology

The common cold coronaviruses are a source of ongoing morbidity and mortality particularly among elderly and immunocompromised individuals. While cross-reactive immune responses against multiple coronaviruses have been described following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, it remains unclear if these confer any degree of cross-protection against the common cold coronaviruses. A recombinant fowl adenovirus vaccine expressing the SARS-CoV-2 spike protein (FAdV-9-S19) was generated, and protection from SARS-CoV-2 challenge was shown in K18-hACE2 mice. Vaccinated mice were also challenged with the common cold coronaviruses human coronavirus (HCoV)-OC43 and HCoV-NL63 by the intranasal route, and viral shedding and lung burden were reduced in these groups compared to unvaccinated animals. Histopathological analysis of lung tissues revealed significantly less inflammation and lower pathology scores in mice that received FAdV-9-S19 . Because no mouse model for the coronavirus HCoV-229E exists, we vaccinated and challenged cynomolgus macaques to evaluate cross-protection against HCoV-229E. Animals were monitored for clinical signs of disease and viral shedding. Infectious virus was detected in both groups throughout the course of infection; however, vaccinated animals showed reduced viral shedding at multiple time points after infection. Histopathological analysis of lung tissues following challenge also indicated a more moderate di...