An integrated, wearable paper microfluidic array device for multicomponent electrochemical sweat sensing

作者：Qian Yu, Jie Wu, Wencheng Xiao, Chao Zhao, Weiqi Zhang, Yunlong Chen, Ying Liu, Hong Liu, Jun Zhou, Lin Ding, Huangxian Ju · 发表于：Cell Reports Physical Science · 年份：2025 · DOI：10.1016/j.xcrp.2024.102389 · 被引用次数：13 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Tactile and Sensory Interactions、Advanced Chemical Sensor Technologies

Wearable sweat-sensing devices hold great promise for personalized healthcare but are facing substantial challenges in industrialization due to the lack of simple and efficient on-skin sweat-sampling modules. Here, we design a mass-producible paper microfluidic array with 96 inlets for tandem sweat collection, effective sampling (12 μL min −1 ), and quick refilling (2 min). This microfluidic array can be conveniently worn on different parts of the body and integrated with a flexible electrochemical sensor array, which has been demonstrated with the newly developed array of Na + , K + , H + , glucose, and lactate sensors, and a printed circuit board for Bluetooth-controlled signal processing. Continuous analysis of sweat metabolites and electrolytes can be achieved to directly visualize the results on a custom-smartphone app. On-body tests demonstrate the feasibility of this skin-mounted, wearable device for continuous perspiration collection and multicomponent monitoring, demonstrating its practical application prospects.