Application of Deep Eutectic Solvents with Modern Extraction Techniques for the Recovery of Natural Products: A Review

作者：Mengting Fu, Huimin Zhang, Jinling Bai, Mengting Cui, Zhiyu Liu, Xiangjie Kong, Wenbin Zhang, Ping Wang, Wang Yuan, Liyun Kong · 发表于：ACS Food Science & Technology · 年份：2025 · DOI：10.1021/acsfoodscitech.4c00973 · 被引用次数：29 · 研究领域：Ionic liquids properties and applications、Analytical Chemistry and Chromatography、Chemical and Physical Properties in Aqueous Solutions

The era of green chemistry has prompted extensive exploration into novel solvents for extracting natural products (NPs) as alternatives to traditional toxic organic solvents. Recently, deep eutectic solvents (DESs) have emerged as promising substitutes for NPs extraction. At the same time, traditional extraction techniques are being replaced to reduce energy consumption, improve extraction efficiency and meet market demands. This review explores the synergistic benefits of combining DESs with modern extraction techniques such as ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pressurized liquid extraction (PLE), and enzyme-assisted extraction (EAE), while also delving into the factors that influence the extraction process. These innovative approaches not only improve yield and reduce extraction time but also help preserve the bioactivity of the extracted compounds. In conclusion, the combination of DESs and modern techniques demonstrates significant potential for extracting bioactive compounds. Ongoing research and development in this field are poised to unlock new applications for DESs in the pharmaceutical, food, and cosmetic industries, driving innovation in natural product extraction methodologies.