Advancements in targeted and immunotherapy strategies for glioma: toward precision treatment

作者：Guangyuan Gong, Lang Jiang, Jing Zhou, Yuanchao Su · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2024.1537013 · 被引用次数：14 · 研究领域：Glioma Diagnosis and Treatment、Nanoplatforms for cancer theranostics、Immune cells in cancer

In recent years, significant breakthroughs have been made in cancer therapy, particularly with the development of molecular targeted therapies and immunotherapies, owing to advances in tumor molecular biology and molecular immunology. High-grade gliomas (HGGs), characterized by their high malignancy, remain challenging to treat despite standard treatment regimens, including surgery, radiotherapy, chemotherapy, and tumor treating fields (TTF). These therapies provide limited efficacy, highlighting the need for novel treatment strategies. Molecular targeted therapies and immunotherapy have emerged as promising avenues for improving treatment outcomes in high-grade gliomas. This review explores the current status and recent advancements in targeted and immunotherapeutic approaches for high-grade gliomas.