A hypoxia-targeting and hypoxia-responsive nano-probe for tumor detection and early diagnosis

作者：Yong Chen, Huimin Wang, Xiaodan Xu, Hongxia Xu, Bing Xiao, Pengcheng Yuan, Shiqun Shao, Wenjing Sun, Zhuxian Zhou, Youqing Shen, Jianbin Tang · 发表于：Biomaterials Science · 年份：2025 · DOI：10.1039/d4bm01499e · 被引用次数：4 · 研究领域：Nanoplatforms for cancer theranostics、Advanced biosensing and bioanalysis techniques、Cancer, Hypoxia, and Metabolism

-oxide moieties and hydrophobic perfluorobenzene ring structures, which highly improved the loading content and water solubility of PtPFPP. By combining targeting and response abilities toward hypoxic conditions, the HTRNP micelles efficiently accumulate in the tumor tissues and emit intense phosphorescence, thus enabling ultrasensitive detection of various tumor models, even of hundreds of cancer cells, indicating its promising potential for early cancer detection and phenotypic characterization.