Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

作者：Hooman Hefzi, Iván Martínez‐Monge, Igor Marín de Mas, Nicholas Luke Cowie, Alejandro Gómez Toledo, Soo Min Noh, Karen Julie la Cour Karottki, Marianne Decker, Johnny Arnsdorf, Jose Manuel Camacho-Zaragoza, Stefan Kol, Sanne Schoffelen, Nuša Pristovšek, Anders Holmgaard Hansen, Antonio Alarcón Miguez, Sara Petersen Bjørn, Karen Kathrine Brøndum, Elham Maria Javidi, Kristian Lund Jensen, Laura Stangl, Emanuel Kreidl, Thomas Beuchert Kallehauge, Daniel Ley, P Ménard, Helle Munck Petersen, Zulfiya Sukhova, Anton Bauer, Emilio Casanova, Niall Barron, Johan A. Malmström, Lars Keld Nielsen, Gyun Min Lee, Helene Faustrup Kildegaard, Bjørn Gunnar Rude Voldborg, Nathan E. Lewis · 发表于：Nature Metabolism · 年份：2025 · DOI：10.1038/s42255-024-01193-7 · 被引用次数：24 · 研究领域：Viral Infectious Diseases and Gene Expression in Insects、Microbial Metabolic Engineering and Bioproduction、CRISPR and Genetic Engineering