The association between neutrophil to high-density lipoprotein cholesterol ratio and gallstones: a cross-sectional study

作者：Yinkang Wang, Xingchen Shang, Yinchao Zhang, Yu Zhang, Wei Shen, Qian Wu, Wenyi Du · 发表于：BMC Public Health · 年份：2025 · DOI：10.1186/s12889-025-21392-5 · 被引用次数：10 · 研究领域：Gallbladder and Bile Duct Disorders、Pediatric Hepatobiliary Diseases and Treatments、Appendicitis Diagnosis and Management

OBJECTIVE: Several studies have discussed the relationship between cholesterol and gallstones, and high-density lipoprotein cholesterol (HDL-C) as a representative of this has been addressed in various diseases. The metric neutrophil to high-density lipoprotein cholesterol ratio (NHR) derived from HDL-C has attracted much attention. The purpose of this article is to examine the relationship between NHR and gallstones in a population of American adults. METHODS: This study investigated the correlation between NHR and gallstone prevalence among US adults using population-based data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). NHR was derived by dividing the neutrophil count by HDL-C. Data were analyzed using a variety of statistical techniques, such as univariate analysis, multivariate analysis, and subgroup analysis. In addition, a receiver operating characteristic curve (ROC) was used to determine the predictive power of the index for the risk of gallstone prevalence. RESULTS: The trial enrolled 6,954 subjects, among whom 746 patients were diagnosed with gallstones. By fully adjusted multivariate logistic regression analysis in the Model 3 section observed a significant positive association between NHR and gallstones with an odds ratio (OR) of 1.05 and a 95% confidence interval (CI) of (1.01, 1.10). The restricted cubic curve (RCS) had a P-Nonlinear = 0.481, suggesting that the relationship was a near-linear one. The area under the curve (AUC)...