Adhesive and Conductive Hydrogels for the Treatment of Myocardial Infarction

作者：Jialiang Zhao, Ying Chen, Yuanyuan Qin, Yongqi Li, Xiong Lu, Chaoming Xie · 发表于：Macromolecular Rapid Communications · 年份：2025 · DOI：10.1002/marc.202400835 · 被引用次数：11 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Tissue Engineering and Regenerative Medicine、Advanced Sensor and Energy Harvesting Materials

Myocardial infarction (MI) is a leading cause of mortality among cardiovascular diseases. Following MI, the damaged myocardium is progressively being replaced by fibrous scar tissue, which exhibits poor electrical conductivity, ultimately resulting in arrhythmias and adverse cardiac remodeling. Due to their extracellular matrix-like structure and excellent biocompatibility, hydrogels are emerging as a focal point in cardiac tissue engineering. However, traditional hydrogels lack the necessary conductivity to restore electrical signal transmission in the infarcted regions. Imparting conductivity to hydrogels while also enhancing their adhesive properties enables them to adhere closely to myocardial tissue, establish stable electrical connections, and facilitate synchronized contraction and myocardial tissue repair within the infarcted area. This paper reviews the strategies for constructing conductive and adhesive hydrogels, focusing on their application in MI repair. Furthermore, the challenges and future directions in developing adhesive and conductive hydrogels for MI repair are discussed.