Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults

作者：Yu Chen, Huey-Ting Li, Xingguang Luo, Guangfei Li, Jaime S. Ide, Chiang‐Shan R. Li · 发表于：Journal of Psychiatry and Neuroscience · 年份：2025 · DOI：10.1503/jpn.240087 · 被引用次数：10 · 研究领域：Functional Brain Connectivity Studies、Mental Health Research Topics、Transcranial Magnetic Stimulation Studies

BACKGROUND: Genetic variants may confer risk for depression by modulating brain structure and function; evidence has underscored the key role of the subgenual anterior cingulate cortex (sgACC) in depression. We sought to examine how the resting-state functional connectivity (rsFC) of the sgACC was associated with polygenic risk for depression in a subclinical population. METHODS: Following published protocols, we computed seed-based whole-brain sgACC rsFC and calculated polygenic risk scores (PRS) using data from healthy young adults from the Human Connectome Project. We performed whole-brain regression against PRS and severity of depression symptoms in a single model for all participants and by sex, controlling for age, sex, race or ethnicity, alcohol use severity, and household income. We evaluated the results at a corrected threshold. RESULTS: We included data for 717 healthy young adults. We found lower rsFC between the sgACC and the default mode network and frontal regions in association with PRS and lower sgACC-cerebellar rsFC in association with depression severity. We also noted differences by sex in the connectivity correlates of PRS and depression severity. In an additional set of analyses, we observed a significant correlation between PRS and somatic complaints, as well as altered sgACC-somatosensory cortical connectivity in association with the severity of somatic complaints. LIMITATIONS: The current findings should be considered specific to subclinical depression...