Overview of Molecular Prognostication for Common Solid Tumor Histologies – What the Surgeon Should Know

作者：C. Rory Goodwin, Rafael De la Garza Ramos, Chetan Bettegowda, Ori Barzilai, Patel Shreyaskumar, Michael G. Fehlings, Ilya Laufer, Arjun Sahgal, Laurence D. Rhines, Jeremy Reynolds, Áron Lazáry, Alessandro Gasbarrini, Nicolas Dea, Jorrit‐Jan Verlaan, Patricia Zadnik Sullivan, Ziya L. Gokaslan, Charles G. Fisher, Stefano Boriani, John H. Shin, Francis J. Hornicek, Michael H. Weber, Matthew L. Goodwin, Raphaële Charest-Morin, AO Spine Knowledge Forum Tumor · 发表于：Global Spine Journal · 年份：2025 · DOI：10.1177/21925682241250327 · 被引用次数：4 · 研究领域：Management of metastatic bone disease、Bone health and treatments、Spine and Intervertebral Disc Pathology

STUDY DESIGN: Narrative Literature review. OBJECTIVE: To provide a general overview of important molecular markers and targeted therapies for the most common neoplasms (lung, breast, prostate and melanoma) that metastasize to the spine and offer guidance on how to best incorporate them in the clinical setting. METHODS: A narrative review of the literature was performed using PubMed, Google Scholar, Medline databases, as well as the histology-specific National Comprehensive Cancer Network guidelines to identify relevant articles limited to the English language. Relevant articles were reviewed for commonly described molecular mutations or targeted therapeutics, as well as associated clinical outcomes, and surgery-related risks. RESULTS: Molecular markers and targeted therapies have dramatically improved the survival of cancer patients. The increasing importance of prognostic molecular markers and targeted therapies provides rationale for their incorporation into clinical decision-making for patients diagnosed with metastatic spine disease. In this review, we discuss the molecular markers/mutations and targeted therapies associated with the most common malignancies that metastasize to the spine and provide a framework that the surgeon can utilize when evaluating patients for potential intervention. Finally, we provide case examples that highlight the importance of molecular prognostication and therapies in surgical decision-making. CONCLUSION: An integrated understanding of the ...