Network characteristics of comorbid symptoms in alcohol use disorder

作者：Xin Yu, Wen Zhang, Can Wang, Guolin Mi, Xiuzhe Chen, Xiuzhe Chen, Yanhu Wang, Xu Chen, Xu Chen · 发表于：Annals of Medicine · 年份：2025 · DOI：10.1080/07853890.2024.2446691 · 被引用次数：7 · 研究领域：Mental Health Research Topics、Substance Abuse Treatment and Outcomes、Sleep and related disorders

Background Individuals with alcohol use disorder (AUD) often experience symptoms such as anxiety, depression, and decreased sleep quality. Although these are not diagnostic criteria, they may increase dependence risk and complicate treatment. This study aims to analyze comorbidities and their complex relationships in AUD patients through epidemiological surveys and network analysis.Materials and methods Using multi-stage stratified cluster random sampling, we selected 27,913 individuals and identified those with AUD for the study. All screened subjects were assessed with the General Health Questionnaire, Pittsburgh Sleep Quality Index, and Simple Coping Style Questionnaire, and diagnosed according to DSM-IV criteria. Network analysis and visualization were performed in R 4.4.0. The qgraph and bootnet packages in R were used to obtain partial correlation network analysis and node centrality of mental health, sleep quality, and coping styles in individuals with AUD through the estimateNetwork function. The bootnet package was used to assess the accuracy and stability of the network. The bnlearn package in R was used to construct directed acyclic graph (DAG) for individuals with AUD using the Bayesian hill-climbing algorithm.Results In the partial correlation network, among the three major comorbidity categories, ‘anxiety/depression’ was most strongly associated with ‘sleep quality’. ‘Anxiety/depression’ and ‘sleep quality’ had the highest node centrality, with ‘sleep latency’ a...