An integrated paper-based microfluidic platform for screening of early-stage Alzheimer's disease by detecting Aβ42

作者：Sixuan Duan, Tianyu Cai, Lizhe Chen, Xiaoyan Wang, Shuailong Zhang, Bing Han, Eng Gee Lim, Kai F. Hoettges, Yong Hu, Pengfei Song · 发表于：Lab on a Chip · 年份：2025 · DOI：10.1039/d4lc00748d · 被引用次数：10 · 研究领域：Biosensors and Analytical Detection、Electrochemical sensors and biosensors、Advanced biosensing and bioanalysis techniques

, a coefficient of determination (COD) of 0.994, and an individual assay time of ∼30 minutes. In addition, we simulated 24 artificial samples to quantify Aβ42 protein concentrations in artificial plasma samples. The results show good consistency between the conventional ELISA and RAPID detection. The experimental results demonstrate that the RAPID is expected to promote further popularization of the screening of early-stage AD.