Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study

作者：Suzanne D. Vernon, Tianyu Zheng, Hyungrok Do, Vincent C. Marconi, Leonard A. Jason, Nora G. Singer, Benjamin H. Natelson, Zaki A. Sherif, Hector Bonilla, Emily Taylor, Janet Mullington, Hassan Ashktorab, Adeyinka O. Laiyemo, Hassan Brim, Thomas F. Patterson, Teresa Akintonwa, Anisha Sekar, Michael J. Peluso, Nikita Maniar, Lucinda Bateman, Leora I. Horwitz, Rachel Hess · 发表于：Journal of General Internal Medicine · 年份：2025 · DOI：10.1007/s11606-024-09290-9 · 被引用次数：56 · 研究领域：Fibromyalgia and Chronic Fatigue Syndrome Research、Long-Term Effects of COVID-19、Exercise and Physiological Responses

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may occur after infection. How often people develop ME/CFS after SARS-CoV-2 infection is unknown. OBJECTIVE: To determine the incidence and prevalence of post-COVID-19 ME/CFS among adults enrolled in the Researching COVID to Enhance Recovery (RECOVER-Adult) study. DESIGN, SETTING, AND PARTICIPANTS: RECOVER-Adult is a longitudinal observational cohort study conducted across the U.S. We included participants who had a study visit at least 6 months after infection and had no pre-existing ME/CFS, grouped as (1) acute infected, enrolled within 30 days of infection or enrolled as uninfected who became infected (n=4515); (2) post-acute infected, enrolled greater than 30 days after infection (n=7270); and (3) uninfected (1439). MEASUREMENTS: Incidence rate and prevalence of post-COVID-19 ME/CFS based on the 2015 Institute of Medicine ME/CFS clinical diagnostic criteria. RESULTS: The incidence rate of ME/CFS in participants followed from time of SARS-CoV-2 infection was 2.66 (95% CI 2.63-2.70) per 100 person-years while the rate in matched uninfected participants was 0.93 (95% CI 0.91-10.95) per 100 person-years: a hazard ratio of 4.93 (95% CI 3.62-6.71). The proportion of all RECOVER-Adult participants that met criteria for ME/CFS following SARS-CoV-2 infection was 4.5% (531 of 11,785) compared to 0.6% (9 of 1439) in uninfected participants. Post-exertional malaise was the most common ME/CFS symptom in infected p...