Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis

作者：Ye Liu, Ziwei Chen, Chang Li, Tianhan Sun, Xuanmei Luo, Boyue Jiang, Meilan Liu, Qing Wang, Tong Li, Jianfu Cao, Yayu Li, Yuan Chen, Le Kuai, Fei Xiao, Hongtao Xu, Hongyuan Cui · 发表于：BMC Gastroenterology · 年份：2025 · DOI：10.1186/s12876-025-03589-5 · 被引用次数：26 · 研究领域：Gut microbiota and health、Liver Disease and Transplantation、Clostridium difficile and Clostridium perfringens research

OBJECTIVE: Summaries of the relationships between the microbiota and liver cirrhosis and their conclusions are not consistent. This study describes microbial differences in patients with liver cirrhosis by performing a meta-analysis. METHODS: We searched PubMed, Embase, Web of Science, and the Cochrane Library and collected related articles published before March 10, 2024. Ratio of autochthonous to non-autochthonous taxa was calculated as the cirrhosis dysbiosis ratio (CDR). Using a random-effects model, the standard mean deviation (SMD) and 95% confidence interval (CI) were calculated. We subsequently performed subgroup, sensitivity, and publication bias analyses. cirrhosis dysbiosis ratio. RESULTS: A total of 53 eligible papers including 5076 participants were included. The pooled estimates revealed a moderately significant reduction in gut microbiome richness in patients with liver cirrhosis compared with controls, including the Shannon, Chao1, observed species, ACE, and PD indices, but no significant difference was observed for the Simpson index. Over 80% of the studies reported significant differences in β diversity. Families Enterobacteriaceae and Pasteurellaceae, belonging to the phylum Proteobacteria, along with the family Streptococcaceae and the genera Haemophilus, Streptococcus, and Veillonella, were significantly associated with liver cirrhosis compared to the control group. In contrast, the healthy group exhibited a higher abundance of the class Clostridia, parti...