Three new diterpenes from the roots of Salvia miltiorrhiza and their cytotoxicity

作者：Yifan Xia, Zheng Jin-hui, Yansong Li, Ping Yu, Zhe Liu, Jie Zhou, Lei Fang · 发表于：Fitoterapia · 年份：2025 · DOI：10.1016/j.fitote.2025.106392 · 被引用次数：3 · 研究领域：Traditional Chinese Medicine Analysis、Phytochemistry and Biological Activities

Two undescribed oxazole-containing diterpenoids (1-2) and a new diterpenoid (3) were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by extensive HRESIMS and NMR spectroscopic analysis, and the absolute configurations of 1 and 3 were confirmed by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 represents the first example of an abietane diterpenoid with a benzo[d]oxazole unit fused in the ring B of the abietane skeleton. The cytotoxicity of 1-3 was evaluated against four human tumor cell lines (A549, MCF-7, HepG2, and PC-3), and 1-2 showed weak cytotoxic activities.