Bivalirudin functionalized hydrogel coating capable of catalytical NO-generation for enhanced anticorrosion and biocompatibility of magnesium alloy

作者：Changjiang Pan, Naiquan Yang, Jie Chen, Qiuyang Zhang, Linhong Deng, Teng Luo, Lingjie Meng · 发表于：Materials Today Bio · 年份：2025 · DOI：10.1016/j.mtbio.2025.101473 · 被引用次数：26 · 研究领域：Magnesium Alloys: Properties and Applications、Hydrogen Storage and Materials、Layered Double Hydroxides Synthesis and Applications

Magnesium and its alloys are undoubtedly ideal candidates for manufacturing new bioabsorbable vascular stents thanks to their good bio-absorbability and better mechanical characteristics. However, the bottlenecks that restrict their clinical application, such as fast corrosion in vivo , poor hemocompatibility, and inferior surface endothelial regeneration ability, have not been resolved fundamentally. In this study, a polydopamine (PDA) intermediate layer covalently linked with acrylamide was first constructed on the alkali-heat-treated magnesium alloys, followed by in-situ polymerizing methacryloyloxyethyl sulfonyl betaine (SBMA) and acrylamide (AAM) to fabricate a hydrogel coating on the surface by ultraviolet (UV) polymerization. Finally, bivalirudin and selenocystamine were sequentially grafted onto the hydrogel coating surface to construct a multifunctional bioactive corrosion-resistant coating with excellent antifouling, anticoagulant performance, and catalytic liberation of NO (nitric oxide) to facilitate endothelial cell (EC) growth. The outcomes verified that the bioactive coating could not only significantly resist corrosion of magnesium alloys, but also had excellent hydrophilicity and the ability to selectively promote albumin adsorption, which could prevent platelet adhesion and activation and significantly diminish the hemolysis occurrence, thereby considerably facilitating its anticoagulant properties. At the same time, due to the hydrophilicity and extracellul...