Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris

作者：Binbing Shi, Xiaotong Wang, Tongneng Xue, Jie Liu, Wanling Wu, Yuanyuan Luo, Hong Zhu, Defeng Pan · 发表于：International Journal of Cardiology Cardiovascular Risk and Prevention · 年份：2025 · DOI：10.1016/j.ijcrp.2025.200367 · 被引用次数：2 · 研究领域：MicroRNA in disease regulation、GDF15 and Related Biomarkers、Biomarkers in Disease Mechanisms

Objective: To investigate the association between plasma miR-146a expression levels, severity of coronary lesions, and clinical prognosis in patients with unstable angina pectoris (UAP). Methods: A total of 100 patients with UAP and 100 controls were selected for assessment of plasma miRNA-146a expression levels. We assessed the severity of coronary lesions in patients with UAP using the Gensini score. Additionally, we analyzed the correlation between miR-146a expression and the degree of coronary artery stenosis in patients with UAP. The incidence of major adverse cardiovascular events (MACEs) was followed-up for 48 months after hospitalization and discharge. The median grouping method was employed to categorize patients into high- and low-expression groups based on their miR-146a levels. Thereafter, the incidence of MACEs in these groups was analyzed using the Kaplan-Meier method. Results: The plasma expression level of miR-146a in the UAP group was 1.8-fold greater than that in the control group (Z = 6.970, P < 0.001) and correlated with the severity of coronary lesions; a high expression level was associated with a higher Gensini score (P < 0.05). Patients with high miR-146a expression levels showed a significantly higher incidence of MACEs than those with low miR-146a expression levels (log-rank test: P = 0.004). Conclusion: Plasma miR-146a expression levels in patients with UAP correlated with the severity of coronary lesions, and patients with high miR-146a expression ...