Advancement of 3D biofabrication in repairing and regeneration of cartilage defects

作者：Zenghui Zheng, Dongmei Yu, Haoyu Wang, Hao Wu, Zhen Tang, Qi Wu, Pengfei Cao, Zhiyuan Chen, Hai Huang, Xiaokang Li, Chaozong Liu, Zheng Guo · 发表于：Biofabrication · 年份：2025 · DOI：10.1088/1758-5090/ada8e1 · 被引用次数：8 · 研究领域：Osteoarthritis Treatment and Mechanisms、Knee injuries and reconstruction techniques、Total Knee Arthroplasty Outcomes

Three-dimensional (3D) bioprinting, an additive manufacturing technology, fabricates biomimetic tissues that possess natural structure and function. It involves precise deposition of bioinks, including cells, and bioactive factors, on basis of computer-aided 3D models. Articular cartilage injuries, a common orthopedic issue. Current repair methods, for instance microfracture procedure (MF), autologous chondrocyte implantation (ACI), and osteochondral autologous transfer surgery have been applied in clinical practice. However, each procedure has inherent limitation. For instance, MF surgery associates with increased subchondral cyst formation and brittle subchondral bone. ACI procedure involves two surgeries, and associate with potential risks infection and delamination of the regenerated cartilage. In addition, chondrocyte implantation's efficacy depends on the patient's weight, joint pathology, gender-related histological changes of cartilage, and hormonal influences that affect treatment and prognosis. So far, it is a still a grand challenge for achieving a clinical satisfactory in repairing and regeneration of cartilage defects using conditional strategies. 3D biofabrication provide a potential to fabricate biomimetic articular cartilage construct that has shown promise in specific cartilage repair and regeneration of patients. This review reported the techniques of 3D bioprinting applied for cartilage repair, and analyzed their respective merits and demerits, and limitati...