Association between complete blood cell count-derived inflammatory biomarkers and gallstones prevalence in American adults under 60 years of age

作者：Chang Fu, Junhong Chen, Yongxin Wang, Yibo Yang, Xiaocong Li, Kai Liu · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2024.1497068 · 被引用次数：20 · 研究领域：Gallbladder and Bile Duct Disorders、Inflammatory Biomarkers in Disease Prognosis、Pancreatitis Pathology and Treatment

Background: The trend of gallstones occurring in younger populations has become a noteworthy public health issue. This study aims to investigate the association between complete blood cell count (CBC)-derived inflammatory indicators and gallstones in adults under 60 years of age in the United States. Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020. Associations between CBC-derived inflammatory biomarkers and gallstones were assessed using multivariable logistic regression models, with results presented as odds ratio (OR) and 95% confidence interval (CI). Restricted cubic splines (RCS) were employed to examine potential non-linear relationships. Subgroup analyses were also conducted to explore differences across population subgroups. Results: This study comprised 4,977 participants, among whom 398 were diagnosed with gallstones. After adjusting for confounding variables, the highest quartile of systemic inflammation response index (SIRI) [OR (95%CI): 1.65(1.12,2.43)], systemic immune-inflammation index (SII) [OR (95%CI): 1.53(1.05,2.25)], monocyte-to-lymphocyte ratio (MLR) [OR (95%CI): 1.66(1.16,2.37)], and pan immune inflammatory value (PIV) [OR (95%CI): 1.82(1.23,2.71)] were associated with a significantly increased risk of gallstones compared to the lowest quartiles. RCS plots indicated a nonlinear relationship between several inflammatory biomarkers and gallstones. Conclusion: Our study foun...