Ozone-Free Protocol for Hydrodealkenylation via Peroxide Formation and Fragmentation

作者：Shingo Harada, Rachel L. Cantrell, Tatianna Tyler, Jacob Newman, Isaiah Aguilar, Minghao Wang, Daria Kim, Yingchuan Zhu, Timothy R. Newhouse · 发表于：ChemRxiv · 年份：2025 · DOI：10.26434/chemrxiv-2025-xwbdj · 被引用次数：1 · 研究领域：Chemical Synthesis and Reactions、Catalysis and Oxidation Reactions

Deconstructive hydrodealkenylations are valuable transformations, particularly utilized in the chiral pool-based enantiospecific syntheses. Current approaches to hydrodealkenylations have limitations regarding functional group tolerance, with ozone being a primary reagent in the installation of the peroxyketal intermediate formed prior to Fe(II) induced β-scission. This work details an ozone-free protocol with a selectivity profile that is expected to follow the Mukaiyama peroxidation.