Impact of Adding N -hexylamine to Nickel Metallophotoredox C–N Coupling to Form Diarylamines

作者：Haiyang Wang, Fujun Li, Wenbo Yang, Yuchao Wang, A. A. Miskevich, Valery A. Loiko, Lijing Zhang, Shengyang Tao · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.4c02106 · 被引用次数：4 · 研究领域：Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques、Oxidative Organic Chemistry Reactions

The mechanistic understanding of how alkylamines impact Ni-metallophotoredox C–N coupling to form diarylamines remains unclear. In this study, 12-alkylamines were evaluated as additives to determine their effects on the synthesis of diarylamines in a flow photochemical system. Notably, n -hexylamine demonstrated the most significant promotional effect. Spectroscopic studies and experimental data reveal n -hexylamine substitutes DABCO as a Ni catalyst ligand, enhancing yields particularly in sterically hindered arylamines.