Comparative Effects of Different Exercise Types on Cardiovascular Health and Executive Function in Sedentary Young Individuals

作者：Jinglin Huang, Lu Leng, Min Hu, Xuyan Cui, Yan Xu, Ziqing Liu, Kangle Wang, Jiarui Wu, Shan He, Weiji Deng, Peilun Li, Yilin Chen, Dongdong Gao, Yuan Wei, Junhao Huang · 发表于：Medicine & Science in Sports & Exercise · 年份：2025 · DOI：10.1249/mss.0000000000003645 · 被引用次数：13 · 研究领域：Cardiovascular Health and Disease Prevention、Heart Rate Variability and Autonomic Control、Cardiovascular and exercise physiology

PURPOSE: The present study aimed to compare the impacts of different exercise types on cardiovascular health and executive function (EF) in sedentary young individuals, and to determine the associations between cardiovascular function and EF after exercise. METHODS: Sixty-three sedentary participants were randomly divided into high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), resistance exercise (RE), and control groups. Macro- and microvascular endothelial functions were assessed using brachial artery flow-mediated dilation and fingertip reactive hyperemia index, respectively. Arterial stiffness was evaluated through carotid-femoral pulse wave velocity, ankle-brachial index, and augmentation index. EF performance was evaluated using the Stroop and N -back tasks. Functional near-infrared spectroscopy was employed to measure cortical activation and real-time oxyhemoglobin concentration (Oxy-Hb) changes in different cerebral regions. Key circulating biomarkers for vascular and cognitive function, including brain-derived neurotrophic factor (BDNF), irisin, vascular endothelial growth factor, insulin-like growth factor 1 (IGF-1), and tumor necrosis factor-α, were measured using enzyme-linked immunosorbent assays. RESULTS: Eight weeks of HIIT, MICT, and RE effectively improved macro- and microvascular endothelial function while reducing arterial stiffness in sedentary young individuals. Furthermore, exercise-induced increase in BDNF level was ...