Pharmacokinetics and Tissue Distribution of Albendazole and Its Three Metabolites in Yellow River Carp ( Cyprinus carpio haematopterus ) after Single Oral Administration

作者：Yan Dai, Heying Yang, Fang Yang, Fang Yang, Xing‐Ping Li, Yue Liu, Yang‐Guang Jin, Ze‐En Li, Minghui Duan, Yanni Zhang, Fan Yang, Fan Yang · 发表于：Journal of Agricultural and Food Chemistry · 年份：2025 · DOI：10.1021/acs.jafc.4c08959 · 被引用次数：5 · 研究领域：Pharmaceutical and Antibiotic Environmental Impacts、Malaria Research and Control、Antibiotics Pharmacokinetics and Efficacy

This study aimed to evaluate the pharmacokinetics and tissue distribution of albendazole (ABZ) and its three metabolites─albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO 2 ), and albendazole-2-aminosulfone (ABZ-2-NH 2 –SO 2 )─in Yellow River carp ( Cyprinus carpio haematopterus ) reared at 17.2 ± 1.1 °C after single oral administration of 12 mg/kg body weight (BW) ABZ. The concentrations of ABZ and its metabolites in different samples were measured using high performance liquid chromatography (HPLC). Pharmacokinetic parameters for ABZSO 2 and ABZ-2-NH 2 –SO 2 were not estimated due to their low levels. Pharmacokinetic analysis of ABZ and ABZSO was conducted using average concentration–time data with Phoenix software. The C max values (μg/mL or μg/g) of ABZ in skin-on muscle, plasma, bile, kidney, gills, liver, and intestine were 0.65, 0.70, 1.01, 1.61, 1.71, 2.42, and 3.34, respectively. The elimination half-life ( t 1/2λZ ) of ABZ was longest in skin-on muscle (37.92 h), followed by the liver (32.07 h), gills (31.92 h), bile (31.51 h), kidney (26.96 h), intestine (20.81 h), and plasma (19.86 h). For ABZSO, the C max values (μg/mL or μg/g) in plasma, skin-on muscle, gills, intestine, liver, kidney, and bile were 0.46, 0.76, 0.89, 1.13, 1.54, 1.89, and 3.78, respectively. These findings indicate that ABZ and ABZSO are widely distributed and metabolized slowly in Yellow River carp after single oral administration. The higher ABZ concentrations in the liver and kidney s...