Safety and Efficacy of Remote Ischemic Conditioning in Patients With Intravenous Thrombolysis: The SERIC-IVT Trial

作者：Zhen‐Ni Guo, Reziya Abuduxukuer, Peng Zhang, Yang Qu, Lijuan Wang, Junfeng Zhao, Dongsheng Ju, Junmin Wang, Hui-Min Jin, W Wang, Rui-Hong Teng, Jianhua Gao, Zhi-Mei Yuan, Huifang Gao, Yongfei Jiang, Z. Li, Ying He, Ligang Jiang, Li Li, Xuefeng Hu, Chunli Jiang, Rui Wang, Yue Qi, Hong Xin, Yan Jia, Yu Hong, Hang Jin, Dawei Chen, Duolao Wang, Thanh N. Nguyen, Yi Yang, Fengjiao Zhang, H Zhang, Jiacheng Liu, Jiaxin Ren, Kejia Zhang, Qianyan He, Shuang-Yin Lei, Siji Wang, Wen-Jing Yin, Xiuli Yan, Ye Sun, Zi‐Duo Shen, Jinqi Wang, Ting Wang, De-Wang Pan, Shanjun Tan, Xiankun Zhang, Yang Zheng, Yu Li, Zhiguo Li, Ce Han, Chunying Li, Jing Yao, Feiyue Teng, Liang He, Hongyu Yang, Jianhua Gao, Jincheng Wang, Jing Tang, Jinhua Chen, Li-Li Zhao, Miao Zhang, Weijia Wang, An-Ran Liu, Dongqing Lv, Feng-Lan Zhao, Ji-Liang Gu, Li Yang, Nan Liu, Qi Zhao, Shiwei Li, Shuguo Wang, Yan Cui, Chunfei Wang, Hainan Chen, Luping Zhang, Xue-Xia Zou, Zhong-Rui Pei, Li-Chong Yang, Yumei Chen, Binghua Liu, Guang-Chen Zou, Hongrun Ju, Jingyao Yu, Jin‐Xin Xiao, Juan Sui, Kun Li, Xia Li, Mei-Mei Jiang, Na Sun, Shan Li, Songwei Li, Xiumin Ding, Chunyu Yang, Li Dan, Guangcai Li, Lei Wu, Lili He, Liping Chen, Ming Chang, Tao Li, Wei Gou, Xiaonan Liu, Xiaoying Cheng, Yali Wang, Yun-Fei Ba, Li Liu, Bai-Jing Zhang, Chen-Peng Dong, Xu Han, Hao Li, Jinfeng Li, Jing Xu, Liang Liu, Liming Sun, Liying Zhang, Qidong Sun, Xue Liu, Dong Yang, Zhibo Chen, Zhuang-Hong Shi, An-Ying Wang, Lijie Guo, Ming Liu, Yingying Gu, Yu Wang, Chunyan Ma, Xue Jing, Liang-Yan Liu, Meng Pang, Li Song, Xin Zhang, Xun-Juan Zhang, Yangyang Song, Yu Zhang, Cui Wang, Dan Xu, Dongxue Yang, Fangfang Liu, Fu-Jin Li, Jie Sun, Li-ming Niu, Ling He, Liyan Liu, Shuang Yu, Si-Yin Sun, Tian-Ji Shi, Wenbo Zhang, Wenjuan Ma, Wen-Tong Song, Xiuping Liu, Yan Jia, Y. Li, Yang Qiu, Wei Zhang, Wenmei Su, Xin Li, Yang Yang, Ying-Chao Cai, Yuting Liu · 发表于：Stroke · 年份：2025 · DOI：10.1161/strokeaha.124.048509 · 被引用次数：19 · 研究领域：Cardiac Ischemia and Reperfusion、Antibiotics Pharmacokinetics and Efficacy、Organ Transplantation Techniques and Outcomes

BACKGROUND: Approximately half of the patients with acute ischemic stroke who receive intravenous thrombolysis (IVT) do not achieve an excellent outcome. Remote ischemic conditioning (RIC) as a promising neuroprotective treatment may improve clinical outcomes in this population. This study aimed to assess the efficacy and safety of RIC in patients with IVT. METHODS: This multicenter, participant-blinded, blinded end point, randomized controlled clinical trial included 558 patients with acute ischemic stroke who underwent IVT in 18 hospitals from August 2021 to May 2023. After IVT, patients were randomized 1:1 to the RIC (unilateral upper limb; cuff pressure, 200 mm Hg, twice daily for 7 days) or sham RIC groups (the same procedure; cuff pressure, 60 mm Hg). The primary efficacy outcome was an excellent functional outcome (modified Rankin Scale score, 0–1) at 90 days after IVT. RESULTS: In total, 558 eligible patients were randomized, and 11 (2.0%) were excluded because they did not receive an RIC or sham RIC. Thus, 547 patients (RIC, n=274; sham RIC, n=273) were included in the modified intention-to-treat analysis, of whom 15 patients were lost to follow-up and 532 (95.3%) completed the trial. At 90 days, 62.7% of patients in the RIC group and 56.8% in the sham RIC group had an excellent functional outcome (unadjusted risk ratio, 1.10 [95% CI, 0.96–1.27]; P =0.169). The proportion of patients with any adverse events was 11.2% in the RIC group and 8.1% in the sham RIC group, w...