The effects of interaction between smoking and abdominal obesity on pre-diabetes mellitus

作者：Huali Xiong, Peng Zhao, Fengxun Ma, Dayi Tang, Dai-Qiang Liu · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-85367-7 · 被引用次数：8 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Adipokines, Inflammation, and Metabolic Diseases、Cardiovascular Disease and Adiposity

Limited studies have been conducted on the interaction of smoking and abdominal obesity on the risk of pre-diabetes mellitus (PDM) among rural adults in southwest China. The data was obtained from a cross-sectional survey conducted using a two stage random sampling method around Rongchang district in ChongQing municipality southwest of China in 2022. A total of 3,017 participants aged 40 to 79 years old were included in the study. Multivariate logistic regression analyses were performed to evaluate the associated risk factors for PDM, and the effect of multiplicative and additive interactions between smoking and abdominal obesity were also assessed by indicators including the relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP) and the synergy index (SI). We found that the prevalence of PDM in participants was 38.98% with an average age of (62.14 ± 11.13) years. Following adjustments for confounding variables, current smoking (OR = 1.26, 95%CI:1.04-1.52) and abdominal obesity (OR = 1.4, 95%CI:1.18-1.66) were significantly linked to an elevated risk of PDM. The multiplicative interaction analyses demonstrated that current smoking exhibited a positive association with PDM (OR = 1.32, 95%CI:1.01-1.71), while a similar association was not observed in the case of abdominal obesity with PDM (OR = 1.15, 95%CI:0.94-1.4). A significant additive interaction was observed between current smoking and abdominal obesity in terms of PDM risk (OR...