Risk Factors for Symptoms in Patients With Heterotopic Gastric Mucosa in the Upper Esophagus

作者：Zhenxiang Wang, Ying Chen, Huihui Sun, Jie Xiong, Yu Zeng, Ye Chen, Yan Zhang, Zhiyu Dong, Junwen Wang, Guangbing Duan, Bo Li, Qian Xue, Kejing Sun, Tingting Zhan, Yuanxi Jiang, Shuchang Xu · 发表于：Gastroenterology Research and Practice · 年份：2025 · DOI：10.1155/grp/7658517 · 研究领域：Gastrointestinal disorders and treatments、Eosinophilic Esophagitis、Gastroesophageal reflux and treatments

Goal: This study is aimed at comparing the clinical characteristics and histological types of symptomatic and asymptomatic patients with heterotopic gastric mucosa in the upper esophagus (HGMUE) and exploring the factors influencing the occurrence and severity of laryngopharyngeal reflux (LPR) symptoms in these patients. Background: HGMUE is a potential cause of LPR symptoms. Study: This retrospective analysis evaluated 70 patients with HGMUE using a detailed questionnaire. Clinical, histological, high‐resolution manometry, and 24‐h pH impedance monitoring data were compared between symptomatic ( n = 49) and asymptomatic ( n = 21) patients. Results : The diameter of HGMUE was significantly larger in the symptomatic group ( p < 0.05), and the incidence of LPR symptoms increased with larger diameter grades; male patients were more likely to have LPR symptoms. The incidence of LPR symptoms varied significantly across histological classifications, being highest in patients with the fundic type ( χ 2 = 6.64, p < 0.05). Binary logistic regression analysis identified sex and histological type as risk factors for LPR symptoms, with odds ratios of 8.996 (95% confidence interval (CI): 1.350–59.962) and 8.493 (95% CI: 1.486–48.522), respectively. The mean nocturnal baseline impedance (MNBI) in the upper esophagus was significantly lower in the symptomatic group (1676.82 ± 739.09 Ω vs. 2441.01 ± 604.11 Ω ; p < 0.05). Clinical and demographic characteristics did not significantly...