Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults

作者：Fengxia Yu, Dong Liu, Xia Ma, Yawen Liu, Linkun Cai, Erwei Zhao, Zixu Huang, Zhe Zhang, Tingting Zhang, Peng‐Gang Qiao, Weitao Zheng, Chunyan Guo, Linxue Qian, Pengling Ren, Zhenchang Wang · 发表于：Brain Research Bulletin · 年份：2025 · DOI：10.1016/j.brainresbull.2025.111204 · 被引用次数：4 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Traumatic Brain Injury and Neurovascular Disturbances、Cardiovascular Health and Disease Prevention

PURPOSE: Dobutamine, a sympathomimetic agent, is widely used clinically, influencing cardiac output, heart rate (HR), and blood pressure (BP), which may impact cerebral blood flow (CBF), critical for brain metabolism. However, the effects of dobutamine on CBF and internal carotid artery (ICA) blood flow remain unclear, with contradictory reported in both clinical and animal studies. It is necessary to investigate the effects of dobutamine on cervical and cerebral hemodynamics. This study aimed to evaluate the effects of dobutamine infusion on ICA blood flow and CBF, explore their relationship, and identify factors influencing CBF to facilitate timely monitoring in clinical practice. METHODS: Forty-eight healthy volunteers underwent physiological assessment, ICA ultrasound, and brain magnetic resonance imaging (MRI) data before and after the administration of dobutamine. Paired t and Wilcoxon signed-rank tests were used to analyze changes, while logistic regression explored associations between hemodynamic factors and CBF. RESULTS: Dobutamine infusion significantly increased HR, respiration rate, systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure, while blood oxygen remained stable. Compared with those in the resting state, the peak systolic velocity (Vs), resistance index, pulsatility index, and systolic/diastolic ratio (S/D) increased, whereas end-diastolic velocity (Vd) decreased. ICA diameter and mean velocity showed no significant changes. CBF significantly...