Secondary Metabolites from Tripterygium wilfordii Hook. f.‐Associated Endophytes: Producing Microbes, Structures, and Bioactivities

作者：Cuili Chen, Shan Lu, Yanmin Zou, Yanmin Zou, Di Mao, Di Mao, Hideaki Kakeya · 发表于：Asian Journal of Organic Chemistry · 年份：2025 · DOI：10.1002/ajoc.202400696 · 被引用次数：7 · 研究领域：Natural Compounds in Disease Treatment、Natural product bioactivities and synthesis、Phytochemistry and Bioactivity Studies

Abstract Endophytes have been recognized as important sources for discovering novel bioactive natural products with diverse structures and biological activities. This review focuses on the endophytes of Tripterygium wilfordii Hook. f. ( T. wilfordii ), a famous traditional medicinal plant, and summarizes the producing microbes, chemical diversities, and bioactivities of the metabolites discovered from the T. wilfordii ‐associated endophytes over the past thirty years (1995–2024). One hundred and one metabolites together with their bioactivities from twelve endophytes are systematically reviewed. A comprehensive comparison of the 101 metabolites with those isolated from T. wilfordii reveals that the T. wilfordii ‐associated endophytes produce structurally distinct metabolites with diverse biological activities. To the best of our knowledge, this is the first holistic overview of the T. wilfordii ‐associated endophytes and their secondary metabolites.