Runx2-NLRP3 axis orchestrates matrix stiffness-evoked vascular smooth muscle cell inflammation

作者：Zhiqing Li, Hao Wu, Fang Yao, Yiran Li, Yanjie Li, Si-An Xie, Fang Yu, Yi Fu, Li Wang, Jing Zhou, Wei Kong · 发表于：American Journal of Physiology-Cell Physiology · 年份：2025 · DOI：10.1152/ajpcell.00448.2024 · 被引用次数：10 · 研究领域：Atherosclerosis and Cardiovascular Diseases、Inflammasome and immune disorders、Protein Tyrosine Phosphatases

As a hallmark of chronic kidney disease (CKD), arterial stiffening is related to increased vascular inflammation and cardiovascular morbidity, whereas the underlying mechanism is unclear. The study demonstrates that increased arterial stiffness precedes the onset of vascular inflammation, and matrix stiffness stimulates the transdifferentiation of vascular smooth muscle cells (VSMCs) to an inflammatory phenotype via activating Runx2-NLRP3 signaling, which provides novel insights into CKD-related cardiovascular disorder treatment.