Treatment of cutaneous larva migrans

作者：Luisa Bopp, Nicolai Deresz, Mario Fabri, Esther von Stebut · 发表于：JDDG Journal der Deutschen Dermatologischen Gesellschaft · 年份：2025 · DOI：10.1111/ddg.15611 · 被引用次数：5 · 研究领域：Dermatological diseases and infestations、Travel-related health issues、Body Image and Dysmorphia Studies

Dear Editors, Among travel-associated skin infections, cutaneous larva migrans (cLM) is the most common parasitic disease.1-3 It is caused by hookworms such as Ancylostoma braziliense, Ancylostoma caninum, and Uncinaria stenocephala that reside in the intestines of cats and dogs.4 As the larvae lack certain zinc-dependent metalloproteases for penetration beyond the skin, humans are aberrant hosts. CLM infestations are self-limiting after 1 to 3 months with the death and resorption of the larva. However, antihelminthic treatment is recommended because of persistent pruritus, mental stress due to parasitic infestation and risk of superinfection. There are few studies on the treatment. In fact, most recommendations are based on retrospective evaluations and case reports. According to the German S1-guideline,4 a single dose of oral ivermectin 200 µg per kg body weight (BW) is the treatment of choice. Alternatively, oral albendazole 800 mg per day for 3 days or topical albendazole 10% three times per day for 7–10 days is recommended. However, studies addressing such topical treatment options are lacking. We herein present a retrospective study on cLM infestations in travelers returning to Germany. Data were collected in dermatology and tropical medicine departments of 20 German universities between 2000–20113 and based on the clinical documentation in the patient files. Alongside patient, demographic, travel, and clinical information, our analysis also incorporated data on therape...