Association between pre-pregnancy maternal stress and small for gestational age: a population-based retrospective cohort study

作者：Manman Chen, Qiongjie Zhou, Yuanyuan Li, Lu Qu, Anying Bai, Fangyi Ruan, Yandan Liu, Yu Jiang, Xiaotian Li · 发表于：BMC Medicine · 年份：2025 · DOI：10.1186/s12916-024-03837-7 · 被引用次数：7 · 研究领域：Maternal Mental Health During Pregnancy and Postpartum、Birth, Development, and Health、Stress Responses and Cortisol

BACKGROUND: Maternal stress is a potential factor affecting fetal growth, but it is unknown whether it directly affects fetal growth restriction. This study aims to investigate the association between pre-pregnancy maternal stress with small for gestational age (SGA). METHODS: This study used a population-based retrospective cohort analysis to examine the association between pre-pregnancy maternal stress and SGA in offspring. Data were extracted from the National Preconception Health Care Project (NPHCP), conducted between 2010 and 2012, which encompassed preconception health-related information from 572,989 individuals across various regions in China. Logistic regression models were used to assess the associations between pre-pregnancy maternal stress variables and the risk of SGA. In addition, Synthetic Minority Over-sampling Technique (SMOTE) and Propensity Scores (PS) methods were used to enhance the model's ability to the associations between pre-pregnancy maternal stress and SGA. RESULTS: Pre-pregnancy maternal stress was significantly associated with an increased the risk of SGA in offspring (OR 1.35, 95% CI 1.20 to 1.51, P < 0.001). Stress related to life and economic factors notably increased the risk of SGA across different socio-economic conditions, whereas stress related to friends did not show a statistically significant association (P > 0.05). Specially, individuals with lower socio-economic status that characterized by below high school education levels (OR = 1...