A new protocolized treatment strategy optimizing medical and surgical care leads to improved healing of Crohn’s perianal fistulas

作者：Michael De Gregorio, Leon Shin‐han Winata, Imogen Hartley, Corina Behrenbruch, Susan J. Connor, Basil D’Souza, Chamara Basnayake, Glen Guerra, Michael Johnston, Michael A. Kamm, James Keck, Mark Lust, Ola Niewiadomski, Eugene Ong, Julien D. Schulberg, Ashish Srinivasan, Tom Sutherland, Rodney Woods, Emily K. Wright, William Connell, Alexander Thompson, Nik S. Ding · 发表于：Journal of Crohn s and Colitis · 年份：2025 · DOI：10.1093/ecco-jcc/jjae199 · 被引用次数：5 · 研究领域：Anorectal Disease Treatments and Outcomes、Inflammatory Bowel Disease、Diverticular Disease and Complications

BACKGROUND AND AIMS: Crohn's perianal fistula healing rates remain low. We evaluated the efficacy of a protocolized multidisciplinary treatment strategy optimizing care in adults with Crohn's perianal fistulas. METHODS: A new treatment strategy was established at a single tertiary center. The strategy comprised 3 dynamic stages of care directed toward achieving and maintaining fistula healing. Stage A, active disease, focused on early commencement and proactive escalation of biologic therapies and structured surgical reviews ensuring adequate fistula drainage and conditioning. Stage B, optimized disease with a seton in situ, focused on consideration for seton removal and appropriateness of definitive surgical closure and/or ablative techniques. Stage C, healed disease, focused on proactive care maintenance. Sixty patients were sequentially enrolled and prospectively followed for ≥12 months. Endpoints included clinical healing and radiologic remission in those with clinically active fistulas, and relapse in those with healed fistulas. RESULTS: At baseline, 52% (n = 31) and 48% (n = 29) had clinically active and healed fistulas, respectively. For patients with clinically active fistulas, 71% achieved clinical healing after 22 months, with estimated healing rates of 39% and 84% at 1 and 2 years, respectively. Radiologic remission was achieved in 25%, significantly higher than baseline inclusion rates of 6%. For patients with healed fistulas, 7% experienced clinical relapse after...