Exercise-driven cellular autophagy: A bridge to systematic wellness

作者：Xiaohan Zhou, Yaxi Luo, Xiu‐Qing Yao · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2024.12.036 · 被引用次数：27 · 研究领域：Autophagy in Disease and Therapy、Muscle Physiology and Disorders、Adipose Tissue and Metabolism

• The various transduction pathways by which exercise influences autophagy, including direct mechanotransduction, blood flow shear stress, and myokine release. • How different exercise modalities can activate specific subtypes of cellular autophagy. • The complex signal pathways involved in exercise-induced autophagy activation, which plays a role in maintaining organ function and promoting disease recovery. • Our in-depth exploration of the transmission process of exercise’s beneficial effects from macro to micro levels helps explain its pervasive impact on the body. Exercise enhances health by supporting homeostasis, bolstering defenses, and aiding disease recovery. It activates autophagy, a conserved cellular process essential for maintaining balance, while dysregulated autophagy contributes to disease progression. Despite extensive research on exercise and autophagy independently, their interplay remains insufficiently understood. This review explores the molecular mechanisms of exercise-induced autophagy in various tissues, focusing on key transduction pathways. It examines how different types of exercise trigger specific autophagic responses, supporting cellular balance and addressing systemic dysfunctions. The review also highlights the signaling pathways involved, their roles in protecting organ function, reducing disease risk, and promoting longevity, offering a clear understanding of the link between exercise and autophagy. Exercise-induced autophagy is governed by ...