Microfluidic-based electrically driven particle manipulation techniques for biomedical applications

作者：Jiulin Wang, Xinyuan Cui, Wei Wang, Junhao Wang, Q W Zhang, Xiaonan Guo, Yanfeng Liang, Shujing Lin, Bingfeng Chu, Daxiang Cui · 发表于：RSC Advances · 年份：2025 · DOI：10.1039/d4ra05571c · 研究领域：Microfluidic and Bio-sensing Technologies、Electrowetting and Microfluidic Technologies、Microfluidic and Capillary Electrophoresis Applications

Microfluidic chips exhibit unique advantages in both economy and rapidity, particularly for the separation and detection of biomolecules. In this review, we first introduced the mechanisms of several electrically driven methods, such as electrophoresis, dielectrophoresis, electro-wetting and electro-rotation. We then discussed in detail the application of these methods in nucleic acid analysis, protein manipulation and cell treatment. In addition, we outlined the considerations for material selection, manufacturing processes and structural design of microfluidic chips based on electrically driven mechanisms.